Biological and Chemical Risks

Frontier AI Risk Management Framework (v1.0)

SAIL & Concordia AI (2025)

Source

Sub-category

Risk Domain

4Malicious Actors & Misuse

4.2Cyberattacks, weapon development or use, and mass harm

Using AI systems to develop cyber weapons (e.g., by coding cheaper, more effective malware), develop new or enhance existing weapons (e.g., Lethal Autonomous Weapons or chemical, biological, radiological, nuclear, and high-yield explosives), or use weapons to cause mass harm.

"The dual-use nature of AI technology presents a critical risk by significantly lowering technical thresholds for malicious non-state actors to design, synthesize, acquire, and deploy CBRNE (Chemical, Biological, Radiological, Nuclear, and Explosive) weapons. This capability poses unprecedented challenges to national security, international non-proliferation regimes, and global security governance."(p. 5)

Entity— Who or what caused the harm

Human

Due to a decision or action made by humans

AI system

Due to a decision or action made by an AI system

Other

Due to some other reason or is ambiguous

Intent— Whether the harm was intentional or accidental

Intentional

Due to an expected outcome from pursuing a goal

Unintentional

Due to an unexpected outcome from pursuing a goal

Other

Without clearly specifying the intentionality

Timing— Whether the risk is pre- or post-deployment

Pre-deployment

Occurring before the AI is deployed

Post-deployment

Occurring after the AI model has been trained and deployed

Other

Without a clearly specified time of occurrence

Supporting Evidence (1)

"In the biological domain, AI could facilitate the design of novel pathogens with enhanced virulence, optimize gene editing tools for malicious applications, or accelerate biological weapons development.14 AI systems could enable the creation of "superviruses" combining rapid transmission, high mortality, and extended incubation periods. These scenarios pose severe threats to global public health and ecosystems, potentially triggering widespread biological crises, mass casualty events, or global pandemics.15"(p. 6)